Selected Publications

PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.

Baldrighi M, Doreth C, Li Y, Zhao X, Warner EF, Chenoweth H, Kishore K, Umrania Y, Minde DP, Winkler S, Yu X, Lu Y, Knapton A, Harrison J, Clarke MC, Latz E, de Cárcer G, Malumbres M, Ryffel B, Bryant CE, Liu J, Lilley KS, Mallat Z, Li X.

J Clin Invest. 2023. 133(21):e162129.

This work is featured as JCI cover research article for the 1st-Nov. 2023 issue, and highlighted as the editor’s pick in JCI This Month.

Targeting microtubules for the treatment of heart disease.

Warner E, Li Y, Li X.

Circulation Research. 2022. 130(11):1723-1741.

MARK4 controls ischaemic heart failure through microtubule detyrosination.

Yu X, Chen X, Amrute-Nayak M, Allgeyer E, Zhao A, Chenoweth H, Clement M, Harrision J, Doreth C, Sirinakis G, Krieg T, Zhou H, Huang H, Tokuraku K, St Johnston D, Mallat Z, Li X.

Nature. 2021. 594, 560-565.

This work is one of BHF research highlights of 2021.

MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis.

Clement M, Chen X, Chenoweth HL, Teng Z, Thome S, Newland SA, Harrison J, Yu X, Finigan AJ, Mallat Z, Li X.

Arterioscler Thromb Vasc Biol. 2019. 39(8):1645-1651.

This work is covered by the ATVB Journal front editorial “Enigma of inflammasome activation by kinases”.

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.

Li X, Thome S, Ma XD, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James, JR, Shi YG, Meng GY, Mallat Z.

Nature Communications. 2017. 28;8:15986.

Publication List

  • Li X, Clarke M. Expansion of fibroblast-like cells may explain the CANTOS meta-analysis findings for patients with clonal haematopoiesis. Nat. Cardiovasc. Research. 2024. 3,23-25.

  • Baldrighi M, Doreth C, Li Y, Zhao X, Warner EF, Chenoweth H, Kishore K, Umrania Y, Minde DP, Winkler S, Yu X, Lu Y, Knapton A, Harrison J, Clarke MC, Latz E, de Cárcer G, Malumbres M, Ryffel B, Bryant CE, Liu J, Lilley KS, Mallat Z, Li X. PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models. J Clin Invest. 2023 Sep 12:e162129.

    This work is featured as JCI cover for the 1st-Nov. 2023 issue.

  • Warner E, Li Y, Li X. Targeting microtubules for the treatment of heart disease. Circulation Research. 2022. 130(11):1723-1741.

  • Yu X, Chen X, Amrute-Nayak M, Allgeyer E, Zhao A, Chenoweth H, Clement M, Harrision J, Doreth C, Sirinakis G, Krieg T, Zhou H, Huang H, Tokuraku K, St Johnston D, Mallat Z, Li X. MARK4 controls ischaemic heart failure through microtubule detyrosination. Nature. 2021. 594, 560-565.

          This work is one of BHF research highlights of 2021.

  • Lu Y, Basatemur G, Scott IC, Chiarugi D, Clement M, Harrison J, Jugdaohsingh R, Yu X, Newland SA, Jolin HE, Li X, Chen X, Szymanska M, Haraldsen G, Palmer G, Fallon PG, Cohen ES, McKenzie ANJ, Mallat Z. Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages. Immunity. 2020. 52(5):782-793.e5.

  • Clement M, Chen X, Chenoweth HL, Teng Z, Thome S, Newland SA, Harrison J, Yu X, Finigan AJ, Mallat Z, Li X. MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019. 39(8):1645-1651.  

      Covered by the ATVB Journal front editorial “Enigma of inflammasome activation by kinases”.

  • Baldrighi M, Mallat Z, Li X. NLRP3 inflammasome pathways in atherosclerosis. Atherosclerosis. 2017. 267:127-138.

  • Li X, Thome S, Ma XD, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James, JR, Shi YG, Meng GY, Mallat Z. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nature Communications. 2017. 28;8:15986.

  • Li X, Deroide N, Mallat Z. The role of the inflammasome in cardiovascular diseases. J Mol Med. 2014. 92(4): 307-19.

  • Li X, Deroide N, Mallat Z. MFG-E8 in the vascular System. Book chapter of “MFG-E8 and inflammation” 2014: 85-95

  • Deroide N, Li X, Lerouet D, Van Vré E, Baker L, Harrison J, Poittevin M, Masters L, Nih L, Margaill I, Iwakura Y, Ryffel B, Pocard M, Tedgui A, Kubis N, Mallat Z . MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury. J Clin Invest. 2013. 123(3):1176-81.

  • Sanghavi P, Laxani S, Li X, Bullock S, Gonsalvez G. Dynein associates with oskar mRNPs and is requied for their efficient net plus-end localization in Drosophila oocytes. PloS One. 2013. 8(11): e80605.

  • Li X, Kuromi H, Brigg L, Green DB, Rocha J, Sweeney S, Bullock SL. BicD binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling. EMBO Journal. 2010. 29(5): 992-1006. Covered by the EMBO Journal front headline article “The more, the better: the BICD family gets bigger”. 

  • Dienstbier M, Li X. BicD and its role in cargo sorting by microtubule-based motors. Biochem Soc. Trans. 2009. 37(Pt 5): 1066-1071.

  • Dienstbier M, Boehl F, Li X, Bullock SL. Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor. Genes & Development. 2009. 23 (13): 1546-1558.

  • Li X, Brunton V, Burgar H, Wheldon L, Heath JK. FRS2-dependent Src activation is required for FGFR-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci. 2004. 117:6007-6017. 

  • Tang Z, Zhao Y, Mei F, Yang S, Li X, Lv J, Hou L, Zhang B. Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT. Biochem Biophys Res Commun. 2004. 324:1324-1332.

  • Wang Q, Bai Z, Li X, Hou L, Zhang B. The evidence of human Orphan Receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription. Cancer Lett. 2004. 214:81-90. 

  • Li X, Wheldon L, Heath JK. Sprouty: a controversial role in receptor tyrosine kinase signalling pathways. Biochem Soc. Trans. 2003. 31: 1445-1446.